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Friday, March 18, 2016

Extracting Neandertal and Denisovan DNA from the genomes of present-day Melanesians

Open access at Science:

Abstract: Although Neandertal sequences that persist in the genomes of modern humans have been identified in Eurasians, comparable studies in people whose ancestors hybridized with both Neandertals and Denisovans are lacking. We developed an approach to identify DNA inherited from multiple archaic hominin ancestors and applied it to whole-genome sequences from 1523 geographically diverse individuals, including 35 new Island Melanesian genomes. In aggregate, we recovered 1.34 Gb and 303 Mb of the Neandertal and Denisovan genome, respectively. We leverage these maps of archaic sequence to show that Neandertal admixture occurred multiple times in different non-African populations, characterize genomic regions that are significantly depleted of archaic sequence, and identify signatures of adaptive introgression.

Vernot et al., Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals, Science 17 Mar 2016, DOI: 10.1126/science.aad9416


Karl_K said...

Davidski said...

Nice one. Thanks.